GLOSSARY

Blood-brain barrier: The blood-brain barrier prevents potentially harmful substances in the blood from entering the brain. Endothelial cells in the small blood vessels are packed much more densely in the brain than in other parts of the body, making it more difficult for substances to pass out of the bloodstream. In general, fat-soluble molecules penetrate the brain while molecules that are not fat-soluble do not. However, certain factors can affect the effectiveness of the blood brain barrier.